Genotyping, sequencing and analysis of 140,000 adults from Mexico City.

ABSTRACT: The Mexico City Prospective Study is a prospective cohort of more than 150,000 adults recruited two decades ago from the urban districts of Coyoacán and Iztapalapa in Mexico City¹. Here we generated genotype and exome-sequencing data for all individuals and whole-genome sequencing data for 9,950 selected individuals. We describe high levels of relatedness and substantial heterogeneity in ancestry composition across individuals. Most sequenced individuals had admixed Indigenous American, European and African ancestry, with extensive admixture from Indigenous populations in central, southern and southeastern Mexico. Indigenous Mexican segments of the genome had lower levels of coding variation but an excess of homozygous loss-of-function variants compared with segments of African

SUBMITTER: Ziyatdinov A 

PROVIDER: S-EPMC10600010 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature