Necroptosis-related genes are associated with prognostic features of kidney renal clear cell carcinoma.

ABSTRACT:

Introduction

Renal clear cell carcinoma is a common type of cancer in the adult urological system. It has a high mortality rate, with 30% of patients developing metastasis and 60% dying within 1-2 years of diagnosis. Recent advancements in tumor immunology and necroptosis have provided new insights into kidney cancer therapy. Therefore, it is crucial to identify potential targets for combining immunotherapy with necroptosis.

Materials and methods

Using the GSE168845 dataset and necroptosis-related genes, we identified genes that are differentially expressed in relation to necroptosis. We analyzed the prognostic value of these genes through differential expression analysis, prognostic analysis, and Cox regression analysis. The expression levels of the MYCN and CDKN2A genes we

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10600093 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature