Ebf3⁺ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.

ABSTRACT: Lympho-hematopoiesis is regulated by cytokines; however, it remains unclear how cytokines regulate hematopoietic stem cells (HSCs) to induce production of lymphoid progenitors. Here, we show that in mice whose CXC chemokine ligand 12 (CXCL12) is deleted from half HSC niche cells, termed CXC chemokine ligand 12 (CXCL12)-abundant reticular (CAR) cells, HSCs migrate from CXCL12-deficient niches to CXCL12-intact niches. In mice whose CXCL12 is deleted from all Ebf3⁺/leptin receptor (LepR)⁺ CAR cells, HSCs are markedly reduced and their ability to generate B cell progenitors is reduced compared with that to generate myeloid progenitors even when transplanted into wild-type mice. Additionally, CXCL12 enables the maintenance of B lineage repopulating ability of HSCs in vitro

SUBMITTER: Nakatani T 

PROVIDER: S-EPMC10600098 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature