New gene signature from the dominant infiltration immune cell type in osteosarcoma predicts overall survival.

ABSTRACT: The immune microenvironment of osteosarcoma (OS) has been reported to play an important role in disease progression and prognosis. However, owing to tumor heterogeneity, it is not ideal to predict OS prognosis by examining only infiltrating immune cells. This work aimed to build a prognostic gene signature based on similarities in the immune microenvironments of OS patients. Public datasets were used to examine the correlated genes, and the most consistent dominant infiltrating immune cell type was identified. The LASSO Cox regression model was used to establish a multiple-gene risk prediction signature. A nine-gene prognostic signature was generated from the correlated genes for M0 macrophages and then proven to be effective and reliable in validation cohorts. Signature comparison indicat

SUBMITTER: Gong L 

PROVIDER: S-EPMC10600156 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature