Automated maternal behavior during early life in rodents (AMBER) pipeline.

ABSTRACT: Mother-infant interactions during the early postnatal period are critical for infant survival and the scaffolding of infant development. Rodent models are used extensively to understand how these early social experiences influence neurobiology across the lifespan. However, methods for measuring postnatal dam-pup interactions typically involve time-consuming manual scoring, vary widely between research groups, and produce low density data that limits downstream analytical applications. To address these methodological issues, we developed the Automated Maternal Behavior during Early life in Rodents (AMBER) pipeline for quantifying home-cage maternal and mother-pup interactions using open-source machine learning tools. DeepLabCut was used to track key points on rat dams (32 points) and indivi

SUBMITTER: Lapp HE 

PROVIDER: S-EPMC10600172 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature