KDM5 family of demethylases promotes CD44-mediated chemoresistance in pancreatic adenocarcinomas.

ABSTRACT: A growing body of evidence suggests that the histone demethylase-lysine demethylase 5 (KDM5) family is associated with drug resistance in cancer cells. However, it is still not clear whether KDM5 family members promote chemotherapy resistance in pancreatic ductal adenocarcinomas (PDAC). Comprehensive bioinformatics analysis was performed to investigate the prognostic value, and functional mechanisms of KDM5 family members in PDAC. The effects of KDM5 family members on drug resistance in PDAC cells and the relationship with CD44, as a stem cell marker, were explored by gene knockout and overexpression strategies. Finally, our findings were validated by functional experiments such as cell viability, colony formation and invasion assays. We found that the expression of KDM5A/C was significant

SUBMITTER: Wang D 

PROVIDER: S-EPMC10600175 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature