Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease.

ABSTRACT: Post-infectious conditions present major health burdens but remain poorly understood. In Chagas disease (CD), caused by Trypanosoma cruzi parasites, antiparasitic agents that successfully clear T. cruzi do not always improve clinical outcomes. In this study, we reveal differential small molecule trajectories between cardiac regions during chronic T. cruzi infection, matching with characteristic CD apical aneurysm sites. Incomplete, region-specific, cardiac small molecule restoration is observed in animals treated with the antiparasitic benznidazole. In contrast, superior restoration of the cardiac small molecule profile is observed for a combination treatment of reduced-dose benznidazole plus an immunotherapy, even with less parasite burden reduction. Overall, these results reveal molecula

SUBMITTER: Liu Z 

PROVIDER: S-EPMC10600178 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature