Load sharing between synergistic muscles characterized by a ligand-binding approach and elastography.

ABSTRACT: The skeletal muscle contraction is determined by cross-bridge formation between the myosin heads and the actin active sites. When the muscle contracts, it shortens, increasing its longitudinal shear elastic modulus ([Formula: see text]). Structurally, skeletal muscle can be considered analogous to the molecular receptors that form receptor-ligand complexes and exhibit specific ligand-binding dynamics. In this context, this work aims to apply elastography and the ligand-binding framework to approach the possible intrinsic mechanisms behind muscle synergism. Based on the short-range stiffness principle and the acoustic-elasticity theory, we define the coefficient [Formula: see text], which is directly related to the fraction saturation of molecular receptors and links the relative longitudin

SUBMITTER: Grinspan GA 

PROVIDER: S-EPMC10600237 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature