Metabolomic profiling of preterm birth in pregnant women living with HIV.

ABSTRACT:

Background

Preterm birth is a leading cause of death in children under the age of five. The risk of preterm birth is increased by maternal HIV infection as well as by certain antiretroviral regimens, leading to a disproportionate burden on low- and medium-income settings where HIV is most prevalent. Despite decades of research, the mechanisms underlying spontaneous preterm birth, particularly in resource limited areas with high HIV infection rates, are still poorly understood and accurate prediction and therapeutic intervention remain elusive.

Objectives

Metabolomics was utilized to identify profiles of preterm birth among pregnant women living with HIV on two different antiretroviral therapy (ART) regimens.

Methods

This pilot study comprised 100 mother-infant dyads p

SUBMITTER: Tobin NH 

PROVIDER: S-EPMC10600291 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature