Effect of mechanical stimulation on tissue heterotopic ossification: an in vivo experimental study.

ABSTRACT: Background: Heterotopic ossification of tendons and ligaments (HOTL) is a common clinical condition characterized by the absence of discernible features and a lack of effective treatment. In vitro experiments have demonstrated that mechanical stimulation can induce cell differentiation toward osteogenesis, thereby promoting heterotopic ossification. Currently, there are few experimental designs aimed at inducing ligament stretching in mice, and the mechanism of heterotopic ossification may not entirely mirror that observed in clinical cases. Therefore, there is an urgent imperative to develop a novel and feasible animal model. Methods: In this study, all the Enpp1 gene deficiency mice (a mouse model with heterotopic ossification of multiple ligaments) were divid

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC10600381 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature