Mathematical modeling of radiotherapy: impact of model selection on estimating minimum radiation dose for tumor control.

ABSTRACT:

Introduction

Radiation therapy (RT) is one of the most common anticancer therapies. Yet, current radiation oncology practice does not adapt RT dose for individual patients, despite wide interpatient variability in radiosensitivity and accompanying treatment response. We have previously shown that mechanistic mathematical modeling of tumor volume dynamics can simulate volumetric response to RT for individual patients and estimation personalized RT dose for optimal tumor volume reduction. However, understanding the implications of the choice of the underlying RT response model is critical when calculating personalized RT dose.

Methods

In this study, we evaluate the mathematical implications and biological effects of 2 models of RT response on dose personalization: (1) cytotoxi

SUBMITTER: Kutuva AR 

PROVIDER: S-EPMC10600389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature