Dysregulation of circulating T follicular helper cell subsets and their potential role in the pathogenesis of syphilis.

ABSTRACT:

Introduction

The role of the host immune response could be critical in the development of Treponema pallidum (Tp) infection in individuals with latent syphilis. This study aims to investigate the alterations in T follicular helper T (Tfh) cell balance among patients with secondary syphilis and latent syphilis.

Methods

30 healthy controls (HCs), 24 secondary syphilis patients and 41 latent syphilis patients were enrolled. The percentages of total Tfh, ICOS⁺ Tfh, PD-1⁺ Tfh, resting Tfh, effector Tfh, naïve Tfh, effector memory Tfh, central memory Tfh,Tfh1, Tfh2, and Tfh17 cells in the peripheral blood were all determined by flow cytometry.

Results

The percentage of total Tfh cells was significantly higher in secondary syphilis patients compared to

SUBMITTER: Shen F 

PROVIDER: S-EPMC10600468 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature