Personalized Initial Screening Age for Colorectal Cancer in Individuals at Average Risk.

ABSTRACT:

Importance

Colorectal cancer (CRC) risk varies widely in the population at average risk without a family history, but there are no established routines for translating this variation into personalized starting ages of screening.

Objective

To illustrate derivation of risk-adapted starting ages of CRC screening based on the concept of risk advancement period (RAP) using sex and a polygenic risk score (PRS) as an example.

Design, setting, and participants

This cohort study included participants in the UK Biobank study recruited in England, Wales, and Scotland between March 13, 2006, and October 1, 2010. Participants were aged 40 to 69 years, with no previous bowel cancer screening and no family history of CRC. Follow-up of cancer data was completed February 29, 2020, for

SUBMITTER: Chen X 

PROVIDER: S-EPMC10600582 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature