Metabolomic Biomarker Signatures for Bipolar and Unipolar Depression.

ABSTRACT:

Importance

Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD) because of overlapping symptoms and the lack of objective diagnostic tools.

Objective

To identify a reproducible metabolomic biomarker signature in patient dried blood spots (DBSs) that differentiates BD from MDD during depressive episodes and assess its added value when combined with self-reported patient information.

Design, setting, and participants

This diagnostic analysis used samples and data from the Delta study, conducted in the UK between April 27, 2018, and February 6, 2020. The primary objective was to identify BD in patients with a recent (within the past 5 years) diagnosis of MDD and current depressive symptoms (Patient Health Questionnaire-9 score of 5 or more)

SUBMITTER: Tomasik J 

PROVIDER: S-EPMC10600716 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature