Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial.

ABSTRACT:

Importance

Among patients receiving mechanical ventilation, tidal volumes with each breath are often constant or similar. This may lead to ventilator-induced lung injury by altering or depleting surfactant. The role of sigh breaths in reducing ventilator-induced lung injury among trauma patients at risk of poor outcomes is unknown.

Objective

To determine whether adding sigh breaths improves clinical outcomes.

Design, setting, and participants

A pragmatic, randomized trial of sigh breaths plus usual care conducted from 2016 to 2022 with 28-day follow-up in 15 academic trauma centers in the US. Inclusion criteria were age older than 18 years, mechanical ventilation because of trauma for less than 24 hours, 1 or more of 5 risk factors for developing acute respiratory dis

SUBMITTER: Albert RK 

PROVIDER: S-EPMC10600720 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature