Intrauterine Growth and Offspring Neurodevelopmental Traits: A Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa).

ABSTRACT:

Importance

Conventional epidemiological analyses have suggested that lower birth weight is associated with later neurodevelopmental difficulties; however, it is unclear whether this association is causal.

Objective

To investigate the relationship between intrauterine growth and offspring neurodevelopmental difficulties.

Design, setting, and participants

MoBa is a population-based pregnancy cohort that recruited pregnant women from June 1999 to December 2008 included approximately 114 500 children, 95 200 mothers, and 75 200 fathers. Observational associations between birth weight and neurodevelopmental difficulties were assessed with a conventional epidemiological approach. Mendelian randomization analyses were performed to investigate the potential causal association

SUBMITTER: D'Urso S 

PROVIDER: S-EPMC10600722 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature