Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.

ABSTRACT: Our understanding of the genetics of the human cerebral cortex is limited both in terms of the diversity and the anatomical granularity of brain structural phenotypes. Here we conducted a genome-wide association meta-analysis of 13 structural and diffusion magnetic resonance imaging-derived cortical phenotypes, measured globally and at 180 bilaterally averaged regions in 36,663 individuals and identified 4,349 experiment-wide significant loci. These phenotypes include cortical thickness, surface area, gray matter volume, measures of folding, neurite density and water diffusion. We identified four genetic latent structures and causal relationships between surface area and some measures of cortical folding. These latent structures partly relate to different underlying gene expression traject

SUBMITTER: Warrier V 

PROVIDER: S-EPMC10600728 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature