Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans.

ABSTRACT:

Background

The non-selective serotonin 2A (5-HT_2A) receptor agonist lysergic acid diethylamide (LSD) holds promise as a treatment for some psychiatric disorders. Psychedelic drugs such as LSD have been suggested to have therapeutic actions through their effects on learning. The behavioural effects of LSD in humans, however, remain incompletely understood. Here we examined how LSD affects probabilistic reversal learning (PRL) in healthy humans.

Methods

Healthy volunteers received intravenous LSD (75 μg in 10 mL saline) or placebo (10 mL saline) in a within-subjects design and completed a PRL task. Participants had to learn through trial and error which of three stimuli was rewarded most of the time, and these contingencies switched in a reversal phase. Compu

SUBMITTER: Kanen JW 

PROVIDER: S-EPMC10600934 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature