Cognitive performance and brain structural connectome alterations in major depressive disorder.

ABSTRACT:

Background

Cognitive dysfunction and brain structural connectivity alterations have been observed in major depressive disorder (MDD). However, little is known about their interrelation. The present study follows a network approach to evaluate alterations in cognition-related brain structural networks.

Methods

Cognitive performance of n = 805 healthy and n = 679 acutely depressed or remitted individuals was assessed using 14 cognitive tests aggregated into cognitive factors. The structural connectome was reconstructed from structural and diffusion-weighted magnetic resonance imaging. Associations between global connectivity strength and cognitive factors were established using linear regressions. Network-based statistics were applied to identify subnetworks of c

SUBMITTER: Gruber M 

PROVIDER: S-EPMC10600941 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature