Splicing alterations in pancreatic ductal adenocarcinoma: a new molecular landscape with translational potential.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective therapies, translating into a low 5-year 12% survival rate, despite extensive clinical efforts to improve outcomes. International cooperative studies have provided informative multiomic landscapes of PDAC, but translation of these discoveries into clinical advances are lagging. Likewise, early diagnosis biomarkers and new therapeutic tools are sorely needed to tackle this cancer. The study of poorly explored molecular processes, such as splicing, can provide new tools in this regard. Alternative splicing of pre-RNA allows the generation of multiple RNA variants from a single gene and thereby contributes to fundamental biological processes by finel

SUBMITTER: Alors-Perez E 

PROVIDER: S-EPMC10601233 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature