Antibody dependent cell-mediated cytotoxicity selection pressure induces diverse mechanisms of resistance.

ABSTRACT: Targeted monoclonal antibody therapy has emerged as a powerful therapeutic strategy for cancer. However, only a minority of patients have durable responses and the development of resistance remains a major clinical obstacle. Antibody-dependent cell-mediated cytotoxicity (ADCC) represents a crucial therapeutic mechanism of action; however, few studies have explored ADCC resistance. Using multiple in vitro models of ADCC selection pressure, we have uncovered both shared and distinct resistance mechanisms. Persistent ADCC selection pressure yielded ADCC-resistant cells that are characterized by a loss of NK cell conjugation and this shared resistance phenotype is associated with cell-line dependent modulation of cell surface proteins that contribute to immune synapse formation and NK c

SUBMITTER: Zahavi DJ 

PROVIDER: S-EPMC10601508 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature