Chronic HCV infection promotes cytotoxicity in antigen-specific CD8⁺ T cells regardless of virus specificity.

ABSTRACT:

Introduction

Despite advancements in hepatitis C virus (HCV) infection treatment, HCV still represents a significant public health burden. Besides progressive hepatic damage, viral persistence has lasting effects on innate and adaptive immune responses. Lack of a complete understanding of the factors driving an effective HCV response contributes to the failure to develop a vaccine for prevention. This study advances the existing knowledge on HCV-specific CD8⁺ T cells and describes the impact of current or past HCV infection on CD8⁺ T cells specific for other viruses.

Methods

We used barcoded-dextramers to identify and sort CD8⁺ T cells specific for HCV, cytomegalovirus, and influenza, and characterized them using single-cell RNA sequencing te

SUBMITTER: Maretti-Mira AC 

PROVIDER: S-EPMC10601542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature