Electrical stimulation of cochlear implant promotes activation of macrophages and fibroblasts under inflammation.

ABSTRACT:

Objectives

The implanted electrodes deliver electric signals to spiral ganglion neurons, conferring restored hearing of cochlear implantation (CI) recipients. Postimplantation intracochlear fibrosis, which is observed in most CI recipients, disturbs the electrical signals and impairs the long-term outcome of CI. The macrophages and fibroblasts activation is critical for the development of intracochlear fibrosis. However, the effect of electric stimulation of cochlear implant (ESCI) on the activity of macrophages and fibroblasts was unclear. In the present study, a human cochlear implant was modified to stimulate cultured macrophages and fibroblasts.

Methods

By measuring cellular marker and the expression level of cytokine production, the polarization and activity of macropha

SUBMITTER: Zhang D 

PROVIDER: S-EPMC10601573 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature