Can Growth Hormone Lead to a Faster Recovery from Guillain-Barre Syndrome? Case Report of the First Therapeutic Use in One Patient.

ABSTRACT: Although the prognosis in Guillain-Barré syndrome (GBS) is generally good, protracted and incomplete courses of recovery can be a heavy burden. Animal studies suggest growth hormone (GH) treatment could stimulate myelin repair and thus accelerate functional recovery in acute polyneuropathy. We report on the first use of GH in GBS. Our objective was to monitor safety and tolerability as well as to evaluate the effect of an off-label GH therapy during recovery from GBS in 1 patient. A 28-year-old male with flaccid tetraparesis caused by pure motor GBS was treated off-label with GH (1 mg/day) for 10 weeks. Muscle strength was measured regularly before, during, and after the treatment over a total span of 330 days. Serum levels of IGF-I were assessed before, during, and after GH treatment. Cha

SUBMITTER: Amereller F 

PROVIDER: S-EPMC10601620 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature