Integration of multiple-omics data to reveal the shared genetic architecture of educational attainment, intelligence, cognitive performance, and Alzheimer's disease.

ABSTRACT: Growing evidence suggests the effect of educational attainment (EA) on Alzheimer's disease (AD), but less is known about the shared genetic architecture between them. Here, leveraging genome-wide association studies (GWAS) for AD (N = 21,982/41,944), EA (N = 1,131,881), cognitive performance (N = 257,828), and intelligence (N = 78,308), we investigated their causal association with the linkage disequilibrium score (LDSC) and Mendelian randomization and their shared loci with the conjunctional false discovery rate (conjFDR), transcriptome-wide association studies (TWAS), and colocalization. We observed significant genetic correlations of EA (r_g = -0.22, p = 5.07E-05), cognitive performance (r_g = -0.27, p = 2.44E-05), and intelligence (r_g = -0.3

SUBMITTER: Wang F 

PROVIDER: S-EPMC10601659 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature