The Use of Crizotinib in Sclerosing Epithelioid Fibrosarcoma with ALK Mutation: A Case Report.
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ABSTRACT:
SUBMITTER: Badran A
PROVIDER: S-EPMC10601707 | biostudies-literature | 2023 Jan-Dec
REPOSITORIES: biostudies-literature
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The Use of Crizotinib in Sclerosing Epithelioid Fibrosarcoma with <i>ALK</i> Mutation: A Case Report.
Badran Ahmed A Steele Clara C Alquaydheb Hisham H Ba Theeb Ahmed A Bawazir Abdulmalik A Elshenawy Mahmoud A MA Atallah Jean Paul JP
Case reports in oncology 20230101 1
Sclerosing epithelioid fibrosarcoma is an ultra-rare and aggressive high-grade fibrosarcoma that was originally described in 1995. More than 100 cases are documented worldwide, with the most extensive case series reporting a high rate of recurrence and metastasis. ALK mutations are commonly seen in soft-tissue sarcomas; however, this is the first known case of an ALK V757M mutation. Here, we present a case using crizotinib in treating an ALK-positive sclerosing epithelioid fibrosarcoma refractor ...[more]
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Project description:BackgroundSclerosing epithelioid fibrosarcoma (SEF) is an extremely rare, aggressive malignant subtype of fibrosarcoma. Only dozens of cases of primary SEF in the bone have been reported so far, without case involving fibula reported in literature to date. Herein we report the first case of primary SEF in the right fibula in a 19-year-old man. In this case report, we firstly give a comprehensive description of fibula SEF, including its complete clinical course and radiological findings.Case presentationA 19-year-old man presented with a half-year history of soreness in the right lower leg. Contrast-enhanced computed tomography (CE-CT) and magnetic resonance imaging (MRI) of the right lower leg were performed. Based on the radiological examinations, a diagnosis of malignant tumor arising in the fibular diaphysis was made. Final diagnosis of primary SEF in the right fibula was confirmed by histopathological and immunohistochemical examinations after surgical resection. The patient had no signs of recurrence or metastasis during a 24-month follow-up.ConclusionWe report an exceedingly rare case of primary SEF in the right fibula and its radiological features with CE-CT and MRI.
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Project description:We used microarrays to detail the global programme of gene expression in SEF tumors and to identify up- and down- regulated genes compared to tumors previously deposited in GEO
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Project description:BackgroundRearrangements of the anaplastic lymphoma kinase (ALK) gene comprise a small subset of non-small cell lung cancer (NSCLC). Patients with NSCLC harboring ALK fusion proteins are sensitive to ALK tyrosine kinase inhibitors (TKIs). Various fusion partners of ALK are being discovered with the application of next-generation sequencing (NGS).Case presentationHere, we report a female patient with metastatic lung adenocarcinoma harboring LMO7-ALK (L15, A20) rearrangement revealed by NGS. The patient received crizotinib as first-line treatment and has achieved partial response with a progression-free survival over 1 year.ConclusionsWe firstly found that the satisfactory response to crizotinib verified the oncogenic activity of LMO7-ALK fusion. Great progression and wide application of NGS facilitate the findings of rare fusion types.
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