Proteomic survey of the DNA damage response in Caulobacter crescentus.

ABSTRACT: The bacterial DNA damage response is a critical, coordinated response to endogenous and exogenous sources of DNA damage. Response dynamics are dependent on coordinated synthesis and loss of relevant proteins. While much is known about its global transcriptional control, changes in protein abundance that occur upon DNA damage are less well characterized at the system level. Here, we perform a proteome-wide survey of the DNA damage response in Caulobacter crescentus. We find that while most protein abundance changes upon DNA damage are readily explained by changes in transcription, there are exceptions. The survey also allowed us to identify the novel DNA damage response factor, YaaA, which has been overlooked by previously published, transcription-focused studies. A similar survey in

SUBMITTER: Tashjian TF 

PROVIDER: S-EPMC10601758 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature