TSLP shapes the pathogenic responses of memory CD4⁺ T cells in eosinophilic esophagitis.

ABSTRACT: The cytokine thymic stromal lymphopoietin (TSLP) mediates type 2 immune responses, and treatments that interfere with TSLP activity are in clinical use for asthma. Here, we investigated whether TSLP contributes to allergic inflammation by directly stimulating human CD4⁺ T cells and whether this process is operational in eosinophilic esophagitis (EoE), a disease linked to variants in TSLP. We showed that about 10% of esophageal-derived memory CD4⁺ T cells from individuals with EoE and less than 3% of cells from control individuals expressed the receptor for TSLP and directly responded to TSLP, as determined by measuring the phosphorylation of STAT5, a transcription factor activated downstream of TSLP stimulation. Accordingly, increased numbers of TSLP-responsive

SUBMITTER: Rochman Y 

PROVIDER: S-EPMC10602003 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature