A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits.

ABSTRACT: There is a long-standing debate about the magnitude of the contribution of gene-environment interactions to phenotypic variations of complex traits owing to the low statistical power and few reported interactions to date. To address this issue, the CHARGE Gene-Lifestyle Interactions Working Group has been spearheading efforts to investigate G×E in large and diverse samples through meta-analysis. Here, we present a powerful new approach to screen for interactions across the genome, an approach that shares substantial similarity to the Mendelian randomization framework. We identified and confirmed 5 loci (6 independent signals) interacting with either cigarette smoking or alcohol consumption for serum lipids, and empirically demonstrated that interaction and mediation are the major contribut

SUBMITTER: Zhu X 

PROVIDER: S-EPMC10602131 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature