Testosterone Deficiency Promotes Arterial Stiffening Independent of Sex Chromosome Complement.

ABSTRACT:

Background

Testosterone plays a vital role in men's health. Lower testosterone level is associated with cardiovascular and cardiometabolic diseases, including inflammation, atherosclerosis, and type 2 diabetes. Testosterone replacement is beneficial or neutral to men's cardiovascular health. Testosterone deficiency is associated with cardiovascular events. Testosterone supplementation to hypogonadal men improves libido, increases muscle strength, and enhances mood. We hypothesized that sex chromosomes (XX and XY) interaction with testosterone plays a role in arterial stiffening.

Methods

We used four core genotype male mice to understand the inherent contribution of sex hormones and sex chromosome complement in arterial stiffening. Age-matched mice were either gonadal intact

SUBMITTER: Sakamuri A 

PROVIDER: S-EPMC10602149 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature