Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
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ABSTRACT:
SUBMITTER: Kelsoe J
PROVIDER: S-EPMC10602152 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
Kelsoe John J Ou Anna A Rosenthal Sara S Adli Mazda M Akiyama Kazufumi K Akula Nirmala N Alda Martin M Amare Azmeraw T AT Ardau Raffaella R Arias Bárbara B Aubry Jean-Michel JM Backlund Lena L Banzato Claudio C Bauer Michael M Baune Bernhard B Bellivier Frank F Benabarre Antonio A Bengesser Susanne S Abesh Bhattacharjee B Biernacka Joanna J Bui Elise E Cervantes Pablo P Chen Guo-Bo GB Chen Hsi-Chung HC Chillotti Caterina C Cichon Sven S Clark Scott S Colom Francesc F Cousins David D Cruceanu Cristiana C Czerski Piotr P Dantas Clarissa C Dayer Alexandre A Degenhardt Franziska F DePaulo J Raymond JR Etain Bruno B Falkai Peter P Fellendorf Frederike F Ferensztajn-Rochowiak Ewa E Forstner Andreas J AJ Frisen Louise L Frye Mark M Fullerton Janice J Gard Sebastien S Garnham Julie J Goes Fernando F Grigoroiu-Serbanescu Maria M Grof Paul P Gruber Oliver O Hashimoto Ryota R Hauser Joanna J Heilbronner Urs U Herms Stefan S Hoffmann Per P Hofmann Andrea A Hou Liping L Jamain Stéphane S Jiménez Esther E Kahn Jean-Pierre JP Kassem Layla L Kato Tadafumi T Kittel-Schneider Sarah S König Barbara B Kuo Po-Hsiu PH Kusumi Ichiro I Dalkner Nina N Laje Gonzalo G Landén Mikael M Lavebratt Catharina C Leboyer Marion M Leckband Susan S Jaramillo Carlos López CL MacQueen Glenda G Maj Mario M Manchia Mirko M Marie-Claire Cynthia C Martinsson Lina L Mattheisen Manuel M McCarthy Michael M McElroy Susan S McMahon Francis F Mitchell Philip P Mitjans Marina M Mondimore Francis F Monteleone Palmiero P Nievergelt Caroline C Nöthen Markus M Novak Tomas T Osby Urban U Ozaki Norio N Papiol Sergi S Perlis Roy R Pfennig Andrea A Potash James J Reich-Erkelenz Daniela D Reif Andreas A Reininghaus Eva E Rietschel Marcella M Rouleau Guy G Rybakowski Janusz K JK Schalling Martin M Schofield Peter P Schubert Klaus Oliver KO Schulze Thomas T Schweizer Barbara B Seemüller Florian F Severino Giovanni G Shekhtman Tatyana T Shilling Paul P Shimoda Kazutaka K Simhandl Christian C Slaney Claire C Squassina Alessio A Stamm Thomas T Stopkova Pavla P Tighe Sarah S Tortorella Alfonso A Turecki Gustavo G Vieta Eduard E Volkert Julia J Witt Stephanie S Wray Naomi N Wright Adam A Young Trevor T Zandi Peter P Zompo Maria Del MD
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Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previ ...[more]
