The relationship between trimethylamine-N-oxide and the risk of acute ischemic stroke: A dose‒response meta-analysis.

ABSTRACT:

Background

Although trimethylamine-N-oxide (TMAO) shows a notable correlation with cardiovascular disease, its association with acute ischemic stroke (AIS) remains uncertain and necessitates further investigation.

Objective

A meta-analysis was conducted to assess the relationship between trimethylamine-N-oxide and acute ischemic stroke.

Methods

We conducted a comprehensive search in PubMed, Embase, Cochrane, CNKI, VIP, Wanfang, and CBM, spanning from their inception to 23 September 2023. The search was consistently updated and supplemented by bibliographies of retrieved articles and previous reviews. A total of 20 eligible studies, including 17 case‒controls and 3 cohort studies, were selected, involving 9141 participants (5283 case group, 3858 control group). For the

SUBMITTER: Hong Y 

PROVIDER: S-EPMC10602245 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature