Relationships between body fat distribution and metabolic syndrome traits and outcomes: A mendelian randomization study.

ABSTRACT:

Background

Obesity is a complex, multifactorial disease associated with substantial morbidity and mortality worldwide. Although it is frequently assessed using BMI, many epidemiological studies have shown links between body fat distribution and obesity-related outcomes. This study examined the relationships between body fat distribution and metabolic syndrome traits using Mendelian Randomization (MR).

Methods/findings

Genetic variants associated with visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), and gluteofemoral adipose tissue (GFAT), as well as their relative ratios, were identified from a genome wide association study (GWAS) performed with the United Kingdom BioBank. GWAS summary statistics for traits and outcomes related to metabolic syndro

SUBMITTER: Huang B 

PROVIDER: S-EPMC10602264 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature