Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices.

ABSTRACT: Intestinal retentive devices have applications ranging from sustained oral drug delivery systems to indwelling ingestible medical devices. Current strategies to retain devices in the small intestine primarily focus on chemical anchoring using mucoadhesives or mechanical coupling using expandable devices or structures that pierce the intestinal epithelium. Here, the feasibility of intestinal retention using devices containing villi-inspired structures that mechanically interlock with natural villi of the small intestine is evaluated. First the viability of mechanical interlocking as an intestinal retention strategy is estimated by estimating the resistance to peristaltic shear between simulated natural villi and devices with various micropost geometries and parameters. Simulations are valid

SUBMITTER: Naik D 

PROVIDER: S-EPMC10602537 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature