Myocardial Fibrosis and Cardiomyopathy Risk: A Genetic Link in the MESA.

ABSTRACT:

Background

Common genetic variants are associated with risk for hypertrophic cardiomyopathy and dilated cardiomyopathy and with left ventricular (LV) traits. Whether these variants are associated with myocardial fibrosis, an important pathophysiological mediator of cardiomyopathy, is unknown.

Methods

Multi-Ethnic Study of Atherosclerosis participants with T1-mapping cardiac magnetic resonance imaging in-whom extracellular volume was assessed, and genotyping information was available were included (N=1255). Log extracellular volume (%) was regressed on 50 candidate single nucleotide polymorphisms (previously identified to be associated with hypertrophic cardiomyopathy, dilated cardiomyopathy, and LV traits) adjusting for age, sex, diabetes, blood pressure, and principal compo

SUBMITTER: Shabani M 

PROVIDER: S-EPMC10602591 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature