Interaction between intratumoral microbiota and tumor mediates the response of neoadjuvant therapy for rectal cancer.

ABSTRACT:

Background

Previous observations have demonstrated that the response to neoadjuvant chemoradiotherapy (nCRT) is highly variable in patients with locally advanced rectal cancer (LARC). Recent studies focusing on the intratumoral microbiota of colorectal cancer have revealed its role in oncogenesis and tumor progression. However, limited research has focused on the influence of intratumoral microbiota on the nCRT of LARC.

Methods

We explored the microbial profiles in the tumor microenvironment of LARC using RNA-seq data from a published European cohort. Microbial signatures were characterized in pathological complete response (pCR) and non-pCR groups. Multi-omics analysis was performed between intratumor microbiomes and transcriptomes.

Results

Microbial α and β diversit

SUBMITTER: Sun L 

PROVIDER: S-EPMC10602640 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature