Significant dysregulation of lipid metabolism in patients with papillary thyroid carcinoma after thyroidectomy.

ABSTRACT:

Introduction

Thyroidectomy and thyrotropin suppressive therapy is the widely used surgical treatment for papillary thyroid carcinoma (PTC) patients. However, systematic metabolic changes of post-operative PTC patients were rarely reported.

Methods

Here, untargeted metabolomic detection of cohorts from PTC before (t0) and 1-month-after (t1) thyroidectomy, were performed to characterize circulating metabolic signatures after surgical treatment.

Results

Our results showed PTC patients exhibited lower thyroid stimulating hormone degree, higher total thyroxine, and significant lipid-related metabolic alternations after thyroidectomy, which included 97 upregulations (including 93 lipids) and 5 downregulations (including 2 lipids and 3 nucleotides). Enrichment of metabolic p

SUBMITTER: Zhou L 

PROVIDER: S-EPMC10602777 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature