Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Purpose

Resistin, a novel pro-inflammatory protein implicated in inflammatory processes, has been suggested to play a role in colorectal development. However, evidence from observational studies has been inconsistent. Mendelian randomization may be a complementary method to examine this association.

Methods

We conducted a two-sample Mendelian randomization to estimate the association between genetically determined circulating resistin concentrations and risk of colorectal cancer (CRC). Protein quantitative trait loci (pQTLs) from the SCALLOP consortium were used as instrumental variables (IVs) for resistin. CRC genetic summary data was obtained from GECCO/CORECT/CCFR (the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, an

SUBMITTER: Pham TT 

PROVIDER: S-EPMC10602946 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature