Detection of metastases using circulating tumour DNA in uveal melanoma.

ABSTRACT:

Background

Approximately 50% of uveal melanoma (UM) patients will develop metastatic disease depending on the genetic features of the primary tumour. Patients need 3-12 monthly scans, depending on their prognosis, which is costly and often non-specific. Circulating tumour DNA (ctDNA) quantification could serve as a test to detect and monitor patients for early signs of metastasis and therapeutic response.

Methods

We assessed ctDNA as a biomarker in three distinct UM cohorts using droplet-digital PCR: (A) a retrospective analysis of primary UM patients to predict metastases; (B) a prospective analysis of UM patients after resolution of their primary tumour for early detection of metastases; and (C) monitoring treatment response in metastatic UM patients.

Results

Cohort

SUBMITTER: Beasley AB 

PROVIDER: S-EPMC10602949 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature