Impact of stenosis resistance and coronary flow capacity on fractional flow reserve and instantaneous wave-free ratio discordance: a combined analysis of DEFINE-FLOW and IDEAL.

ABSTRACT:

Background

The pressure-derived parameters fractional flow reserve (FFR) and the emerging instantaneous wave-free ratio (iFR) are the most widely applied invasive coronary physiology indices to guide revascularisation. However, approximately 15-20% of intermediate stenoses show discordant FFR and iFR, and therapeutical consensus is lacking.

Aims

We sought to associate hyperaemic stenosis resistance index, coronary flow reserve (CFR) and coronary flow capacity (CFC) to FFR/iFR discordance.

Methods

We assessed pressure and flow measurements of 647 intermediate lesions (593 patients) of two multi-centre international studies.

Results

FFR and iFR were discordant in 15% of all lesions (97 out of 647). FFR+/iFR- lesions had similar hyperaemic average peak velocity (h

SUBMITTER: Stegehuis V 

PROVIDER: S-EPMC10602988 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature