Abnormal centriolar biomarker ratios correlate with unexplained bull artificial insemination subfertility: a pilot study.

ABSTRACT: The mechanisms underlying male infertility are poorly understood. Most mammalian spermatozoa have two centrioles: the typical barrel-shaped proximal centriole (PC) and the atypical fan-like distal centriole (DC) connected to the axoneme (Ax). These structures are essential for fertility. However, the relationship between centriole quality and subfertility (reduced fertility) is not well established. Here, we tested the hypothesis that assessing sperm centriole quality can identify cattle subfertility. By comparing sperm from 25 fertile and 6 subfertile bulls, all with normal semen analyses, we found that unexplained subfertility and lower sire conception rates (pregnancy rate from artificial insemination in cattle) correlate with abnormal centriolar biomarker distribution. Fluorescence-bas

SUBMITTER: Turner KA 

PROVIDER: S-EPMC10603076 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature