Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia.

ABSTRACT: The non-receptor protein tyrosine phosphatases gene family (PTPNs) is involved in the tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid leukemia (AML) remains unclear. After a comprehensive evaluation on the expression patterns and immunological effects of PTPNs using a pan-cancer analysis based on RNA sequencing data obtained from The Cancer Genome Atlas, the most valuable gene PTPN2 was discovered. Further investigation of the expression patterns of PTPN2 in different tissues and cells showed a robust correlation with AML. PTPN2 was then systematically correlated with immunological signatures in the AML tumor microenvironment and its differential expression was verified using clinical samples. In addition, a prediction model, being validated and compar

SUBMITTER: Wang X 

PROVIDER: S-EPMC10603079 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature