Transcriptional dissection of symptomatic profiles across the brain of men and women with depression.

ABSTRACT: Major depressive disorder (MDD) is one of the most important causes of disability worldwide. While recent work provides insights into the molecular alterations in the brain of patients with MDD, whether these molecular signatures can be associated with the expression of specific symptom domains remains unclear. Here, we identified sex-specific gene modules associated with the expression of MDD, combining differential gene expression and co-expression network analyses in six cortical and subcortical brain regions. Our results show varying levels of network homology between males and females across brain regions, although the associations between these structures and the expression of MDD remain highly sex specific. We refined these associations to several symptom domains and identified tran

SUBMITTER: Mansouri S 

PROVIDER: S-EPMC10603117 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature