Electrochemical halogen-atom transfer alkylation via α-aminoalkyl radical activation of alkyl iodides.

ABSTRACT: Alkyl halides, widely recognized as important building blocks and reagents in organic synthesis, can serve as versatile alkyl radical precursors in radical-based transformations. However, generating alkyl radicals directly from unactivated alkyl halides under mild conditions remains a challenge due to their extremely low reduction potentials. To address this issue, α-aminoalkyl radicals were employed as efficient halogen-atom transfer (XAT) reagents in the photoredox activation of unactivated alkyl halides. Here, we report an effective electrooxidation strategy for generating alkyl radicals from unactivated alkyl iodides via an electrochemical halogen-atom transfer (e-XAT) process under mild conditions. The α-aminoalkyl radicals generated by anodic oxidation are demonstrated to be efficien

SUBMITTER: Sun X 

PROVIDER: S-EPMC10603137 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature