Deleterious and protective effects of epothilone-D alone and in the context of amyloid β- and tau-induced alterations.

ABSTRACT: Amyloid-β (Aβ) and hyperphosphorylated tau (P-tau) are Alzheimer's disease (AD) biomarkers that interact in a complex manner to induce most of the cognitive and brain alterations observed in this disease. Since the neuronal cytoskeleton is a common downstream pathological target of tau and Aβ, which mostly lead to augmented microtubule instability, the administration of microtubule stabilizing agents (MSAs) can protect against their pathological actions. However, the effectiveness of MSAs is still uncertain due to their state-dependent negative effects; thus, evaluating their specific actions in different pathological or physiological conditions is required. We evaluated whether epothilone-D (Epo-D), a clinically used MSA, rescues from the functional and behavioral alterations produced by

SUBMITTER: Robles-Gomez AA 

PROVIDER: S-EPMC10603193 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature