Indole-3-Propionic Acid, a Gut Microbiota Metabolite, Protects Against the Development of Postoperative Delirium.

ABSTRACT:

Objective

The aim was to determine preoperative gut microbiota metabolites that may be associated with postoperative delirium (POD) development in patients and further study in rodents.

Summary background data

POD occurs in 9% to 50% of older patients undergoing anesthesia/surgery but lacks effective treatments or prevention. High-throughput metabolomics using liquid chromatography with tandem mass spectrometry has accelerated disease-related biomarkers discovery. We performed metabolomic studies in humans to identify potential metabolite biomarkers linked to POD and examined potential mechanisms in rodents.

Methods

We performed a prospective observational cohort study to examine the metabolomic changes that were associated with the development of POD. Then the gut mi

SUBMITTER: Zhou X 

PROVIDER: S-EPMC10603211 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature