Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease.

ABSTRACT:

Introduction

We investigated the correlation between retinal thickness and optic tract integrity in subjects with autosomal dominant Alzheimer's disease (ADAD) causing mutations.

Methods

Retinal thicknesses and diffusion tensor images (DTI) were obtained using optical coherence tomography and magnetic resonance imaging, respectively. The association between retinal thickness and DTI measures was adjusted for age, sex, retinotopy, and correlation between eyes.

Results

Optic tract mean diffusivity and axial diffusivity were negatively correlated with retinotopically defined ganglion cell inner plexiform thickness (GCIPL). Fractional anisotropy was negatively correlated with retinotopically defined retinal nerve fiber layer thickness. There was no correlation between out

SUBMITTER: Adhikari S 

PROVIDER: S-EPMC10603214 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature