Differential expression of immunity-related genes in larval Manduca sexta tissues in response to gut and systemic infection.

ABSTRACT:

Introduction

The midgut epithelium functions as tissue for nutrient uptake as well as physical barrier against pathogens. Additionally, it responds to pathogen contact by production and release of various factors including antimicrobial peptides, similar to the systemic innate immune response. However, if such a response is restricted to a local stimulus or if it appears in response to a systemic infection, too is a rather underexplored topic in insect immunity. We addressed the role of the midgut and the role of systemic immune tissues in the defense against gut-borne and systemic infections, respectively.

Methods

Manduca sexta larvae were challenged with DAP-type peptidoglycan bacteria - Bacillus thuringiensis for local gut infection and Escherichia coli</

SUBMITTER: von Bredow YM 

PROVIDER: S-EPMC10603244 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature