Neural correlates of N-back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders.

ABSTRACT:

Aim

Working memory (WM) deficit represents the most common cognitive impairment in psychiatric and neurodevelopmental disorders, making the identification of its neural substrates a crucial step towards the conceptualization of restorative interventions. We present a meta-analysis focusing on neural activations associated with the most commonly used task to measure WM, the N-back task, in patients with schizophrenia, depressive disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. Showing qualitative similarities and differences in WM processing between patients and healthy controls, we propose possible targets for cognitive enhancement approaches.

Methods

Selected studies, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses g

SUBMITTER: Mencarelli L 

PROVIDER: S-EPMC10603255 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature