No association between inactivated influenza vaccination and influenza viral load at diagnosis among young Japanese children: An observational study of the 2013/2014 through 2017/2018 influenza seasons.

ABSTRACT:

Background

The association between inactivated influenza vaccination and viral load in young children remains unclear.

Methods

During the 2013/2014 to 2017/2018 influenza seasons in Japan, children under 6 years of age with pre-defined influenza-like illness and influenza-positive status by real-time RT-PCR were recruited at pediatric clinics for this observational study. Influenza viral load was measured for the most predominant subtype/lineage in each season. Using median dichotomized viral load as an outcome, a multilevel logistic regression model was applied to estimate the multivariable adjusted odds ratio (MOR) and 95% confidence interval (CI) for higher viral load.

Results

A total of 1,185 influenza-positive children were analyzed. The median log₁₀ v

SUBMITTER: Mukai E 

PROVIDER: S-EPMC10603291 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature